Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells

Francesco Andreozzi; Cristina D'Alessandris; Massimo Federici; Emanuela Laratta; Silvia Del Guerra; Stefano Del Prato; Piero Marchetti; Renato Lauro; Francesco Perticone; Giorgio Sesti

Endocrinology (2004) - Comment
pubmed: 15001544 doi: 10.1210/en.2003-0939 issn: 0013-7227 issn: 1945-7170

Francesco Andreozzi, Cristina D'Alessandris, Massimo Federici, Emanuela Laratta, Silvia Del Guerra, Stefano Del Prato, Piero Marchetti, Renato Lauro, Francesco Perticone, Giorgio Sesti

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The Endocrine Society