APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase
Cell Death & Disease (2013) - Comments
pubmed: 24157875  doi: 10.1038/cddis.2013.417  issn: 2041-4889 

X Peng, M-Q-Z Zhang, F Conserva, G Hosny, G Selivanova, V J N Bykov, E S J Arnér, K G Wiman