Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change.
Proceedings of the National Academy of Sciences of the United States of America (2006) - Comments
doi: 10.1073/pnas.0510664103  pubmed: 16446428  pmc: PMC1413664 

Ewen Gallagher, Min Gao, Yun-Cai Liu, Michael Karin