High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease

Journal of Biological Chemistry (2005) - Comments
pubmed: 16027115 doi: 10.1074/jbc.m507016200 issn: 0021-9258

Edward Rockenstein, Michael Mante, Michael Alford, Anthony Adame, Leslie Crews, Makoto Hashimoto, Luke Esposito, Lennart Mucke, Eliezer Masliah